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subgranular zone
The subgranular zone (SGZ) is a brain region in the hippocampus where adult neurogenesis occurs. It is one of the two major sites of adult neurogenesis in the brain, along with the subventricular zone (SVZ).
== Structure ==
The subgranular zone is a narrow layer of cells located between the granule cell layer and hilus of the dentate gyrus. This layer is characterized by several types of cells, the most prominent type being neural stem cells (NSCs) in various stages of development. However, in addition to NSCs, there are also astrocytes, endothelial cells, blood vessels, and other components, which form a microenvironment that supports the NSCs and regulates their proliferation, migration, and differentiation. The discovery of this complex microenvironment and its crucial role in NSC development has led some to label it as a neurogenic “niche”.〔〔〔 It is also frequently referred to as a vascular, or angiogenic, niche due to the importance and pervasiveness of the blood vessels in the SGZ.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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